Anthem
Group Companies

Top quality service, timely delivery and proactive communication

Anthem
Group Companies

One stop solution for integrated drug discovery, process development and scale-up

Anthem
Group Companies

Anthem works closely with clients on IP related information

Anthem
Group Companies

The only CRO in the country with Microbiology division that provides antiinfectives screening services

Anthem
Group Companies

Proven Track Record for Hit-Identification, Hit to Lead and lead Optimization

Anthem
Group Companies

Highly qualified scientific team with diverse experience

Anthem
Group Companies

Cloning, expression and purification of recombinant proteins from both bacterial and mammalian host systems.

Library Design and Synthesis

  • Anthem’s Library synthesis team has rich experience in catering to the needs of global pharmaceutical and biotech companies in designing and synthesizing scaffolds/ high purity spatially addressed libraries for drug discovery
  • Examples of some target classes are Protein Kinases, Proteases, GPCR, Ion-Channel, NHRs, Phosphodiesterases, Ubiquitin/Proteasome.
  • The library projects are usually approached in three phases:
    • 1. Phase I: Scaffold route scouting, scale-up and representative library step validation
    • 2. Phase II: Library production, purification and analysis
    • 3. Phase III: Creating SD file, packaging and shipping
    These phases can overlap depending on the progress of the project and requirement of the client
  • A tracker containing details of synthesized library compounds would be maintained and details of synthesised compounds are shared with the client in the SD file format
  • Compound identification is done by LC-MS, purity by HPLC and 1H-NMR for representative compounds (based on mutual agreement)
  • The final compounds are packed and shipped in appropriate vials as per specifications
  • All necessary equipments such as microwave synthesizer, parallel column chromatography, Genevac solvent remover, Radley’s carousel 12 plus reaction station, preparative HPLC etc. to carry out library synthesis are in place
  • A specially trained analytical team to cater to preparative does HPLC purification and analysis of compound libraries.
  • Data transfer is done using encryption software or secure e-room

Accreditations
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Integrated Discovery
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Facilities
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