APIs
Anthem offers a diverse portfolio of high-quality Active Pharmaceutical Ingredients (APIs) that cater to various therapeutic areas. With a commitment to innovation, precision and regulatory compliance, Anthem ensures its APIs meet stringent global standards, including USP, IP and JP grades.
Indications
- Hyperprolactinemia, prolactinomas, lactation suppression, Parkinson’s disease, uterine fibroids, acromegaly, erectile dysfunction.
Mechanism of Action
- Cabergoline inhibits prolactin synthesis and release from the anterior pituitary in a dose-dependent manner.
Dosage
- Hyperprolactinemia: Initial dose of 0.25 mg twice weekly; maximum dose of 1 mg twice weekly.
- Lactation suppression: Single dose of 1 mg within 24–27 hours post-delivery.
- Highly pure and stable USP EP-grade Cabergoline.
Anthem Advantage
- Highly pure and stable USP EP-grade Cabergoline.
Cabergoline IP/USP/EP
Cabergoline is an ergot-derived dopamine receptor agonist. Used to treat hyperprolactinemia caused by pituitary adenomas or idiopathic conditions. Anthem offers IP, USP and EP monograph confirmed product.
Indications
- Blood cell disorders caused by folate antagonists, colon cancer (with 5-fluorouracil), anemia due to folic acid deficiency.
Mechanism of Action
Calcium folinate bypasses methotrexate-induced folic acid inhibition by replenishing reduced folate pools.
Dosage
- Megaloblastic anemia: One tablet daily.
Anthem Advantage
- High-purity formulations designed for therapeutic efficacy.
Calcium folinate IP/USP/EP
A metabolically active form of folate (Vitamin B9), available as a calcium salt. Commonly used in oncology to reduce toxicity of methotrexate, treat folate deficiency, and enhance the efficacy of 5-flurouracil. Injectable and oral dosage formats possible.
Indications
- Gynecology, anemia, cardiac health, neuropathy, cognitive performance, geriatrics.
Mechanism of Action
Enhances acetylcholine synthesis for improved memory and reduces homocysteine toxicity.
Anthem Advantage
- Synthetic enrichment ensures 99% purity for superior bioavailability.
L-Methyl Tetrahydrofolate Calcium USP
Biologically active form of folate (Vitamin B9), as calcium salt. Used during folate deficiency, megaloblastic anemia, and as supportive therapy in pregnancy, cardiovascular disease, depression, Contraceptive formula (to mitigate folate deficiency) and schizophrenia. Available with Drug Master file (US – DMF).
Indications
- Contraception, breast cancer management, dysfunctional uterine bleeding.
Mechanism of Action
Exhibits selective estrogenic or anti-estrogenic activity depending on the tissue type. It prevents implantation by creating unfavorable conditions in the uterus.
Dosage
- Dysfunctional uterine bleeding: 60 mg twice weekly for the first 12 weeks; then once weekly for another 12 weeks.
- Contraception: Initial dose of 30 mg twice weekly for the first 12 weeks; followed by once weekly dosing.
Anthem Advantage
- High therapeutic index with proven safety and efficacy.
Ormeloxifene
Ormeloxifene is a third-generation selective estrogen receptor modulator (SERM). Primarily used as a non-hormonal oral contraceptive (weekly dose) and for the treatment of dysfunctional uterine bleeding.
Indications
- Chronic pancreatitis, cystic fibrosis, pancreatic cancer.
Mechanism of Action
Supports immune system health, enhances digestion of fats/proteins/carbohydrates, and aids cardiovascular health by reducing homocysteine levels.
Dosage
- Therapeutic doses range from 25,000–50,000 U based on individual needs.
Anthem Advantage
- Purified enzyme formulations for optimal digestive support.
Pancreatin IP / USP / BP / Enteric Coated
Pancreatic enzyme with lipase, amylase and protease activity derived from pancreas. Used in pancreatic enzyme replacement therapy for conditions like pancreatic insufficiency, cystic fibrosis, chronic pancreatitis, pancreatic cancer, or post-pancreatectomy. Also used as digestive supplement.
Applications
- Brewing industry for beer stabilization.
- Meat tenderization and protein hydrolysis.
- Pharmaceutical use in digestive aids and wound healing formulations.
- Leather processing and paper manufacturing.
- Contact lens cleaning solutions.
Therapeutic Uses
Treats herpes zoster, sore throat, diarrhea, hay fever, psoriasis, infected wounds.
Formulations
- Available in liquid/ syrup/ tablet/ capsule forms with standard strengths such as PapainX USP or Papain Liquid TU150.
Safety Handling
- Avoid prolonged skin contact; store below 10°C in airtight containers.
Papain IP/USP
Papain is a proteolytic enzyme obtained from the latex of raw papaya fruit (Carica papaya). Used as digestive enzyme supplement for protein breakdown, and for anti-inflammatory therapy.
Indications
- Pancreatic enzyme replacement in insufficiency, diarrhea, chronic gastritis, hypochlorhydria, postoperative digestive insufficiency.
Mechanism of Action
- Pepsin hydrolyzes peptide bonds, particularly those involving aromatic amino acids, contributing to partial protein digestion in the gastrointestinal tract.
Applications
- Supports digestion of hard-to-digest proteins.
- Stimulates bile production and liver detoxification.
- Boosts nutrient absorption and prevents deficiencies.
- Separates vitamin B12 from protein for effective utilization.
Safety Handling
- Airtight containers at temperatures below 10°C.
- Avoid prolonged skin contact; rinse thoroughly in case of spillage.
Pepsin IP
Pepsin is a proteolytic enzyme naturally secreted in the stomach, responsible for breaking down proteins into peptides. Acts as a digestive aid in patients with low stomach acid, indigestion, bloating, or heartburn. Commonly prescribed for protein digestion disorders and general digestive insufficiency.
Indications
- Atherosclerosis, hypercholesterolemia, cancer prevention, herpes labialis infections.
Mechanism of Action
- Resveratrol protects cellular DNA from damage caused by free radicals and supports neuroprotection and anti-aging processes.
Applications
- Lowers blood pressure and improves cardiovascular health.
- Enhances insulin sensitivity and joint pain relief.
- Suppresses cancer cells and protects against brain degeneration.
Nutripanzyme Forte / HLP (P) - Vegan Pancreatin
Nutripanzyme Forte is a unique blend of 3 enzymes (Protease, Lipase and amylase) that contains all the basic digestive enzymes as available in animal derived pancreatin (amylase, protease and lipase). Recommended for digestive aid preparations.
Indications
- Anti-inflammatory conditions, bronchitis, sinusitis, laryngitis, gout, fibromyalgia.
Mechanism of Action
- Hydrolyzes bradykinin and histamine to reduce swelling and improve circulation while dissolving fibrin clots and arterial plaques.
Applications
- Treats arthritis, rheumatism, multiple sclerosis.
- Digests scar tissue and prevents fluid retention.
- Reduces blood clots and cysts.
Serratiopeptidase IP/ JP/ Enteric Coated
Serratiopeptidase is a proteolytic enzyme derived from Serratia bacteria commonly used to treat inflammation, pain, and swelling associated with various clinical conditions.
Indications
- CMV retinitis in AIDS patients; CMV disease prevention post-organ transplant; congenital CMV.
Mechanism of Action
Ganciclovir triphosphate inhibits viral DNA synthesis by targeting viral protein kinases.
Dosage
- Adults: Induction dose of 900 mg twice daily for CMV retinitis; maintenance dose of 900 mg once daily. Pediatric doses vary based on age and condition.
Valganciclovir IP/USP
Valganciclovir is an oral prodrug of ganciclovir, belonging to the class of nucleoside analog antivirals. Used in the treatment and prevention of cytomegalovirus (CMV) infections, especially CMV retinitis in AIDS patients and prophylaxis in organ transplant recipients.
Indications
- Non-insulin-dependent diabetes mellitus (NIDDM), steroid-induced diabetes mellitus, glycogen storage disease.
Mechanism of Action
Delays glucose absorption by inhibiting pancreatic alpha-amylase and intestinal alpha-glucosidase enzymes.
Dosage
- Typically administered at a dose of 0.2 mg three times daily before meals; can be increased to 0.3 mg if needed.
Voglibose IP/JP/CP
An alpha-glucosidase inhibitor that delays carbohydrate absorption in the intestine. Prescribed for Type 2 Diabetes Mellitus to control postprandial (after-meal) blood glucose levels, reducing risks of long-term complications.
Indications
- CMV retinitis in AIDS patients; CMV disease prevention post-organ transplant; congenital CMV.
Mechanism of Action
Ganciclovir triphosphate inhibits viral DNA synthesis by targeting viral protein kinases.
Dosage
- Adults: Induction dose of 900 mg twice daily for CMV retinitis; maintenance dose of 900 mg once daily. Pediatric doses vary based on age and condition.
Fungal Diastase IP
Valganciclovir is an oral prodrug of ganciclovir, belonging to the class of nucleoside analog antivirals. Used in the treatment and prevention of cytomegalovirus (CMV) infections, especially CMV retinitis in AIDS patients and prophylaxis in organ transplant recipients.
Indications
- Non-insulin-dependent diabetes mellitus (NIDDM), steroid-induced diabetes mellitus, glycogen storage disease.
Mechanism of Action
Delays glucose absorption by inhibiting pancreatic alpha-amylase and intestinal alpha-glucosidase enzymes.
Dosage
- Typically administered at a dose of 0.2 mg three times daily before meals; can be increased to 0.3 mg if needed.
Bacterial alpha amylase (1:13000) IP
A powerhouse enzyme that liquefies starch rapidly and efficiently to soluble sugars. Widely used in brewing, textiles and starch industries for quick starch breakdown. Potential food ingredient for digestive formulas.
Anthem Biosciences continues to innovate and deliver world-class APIs tailored to meet diverse pharmaceutical needs while adhering to global regulatory standards.