APIs
Anthem offers a diverse portfolio of high-quality Active Pharmaceutical Ingredients (APIs) that cater to various therapeutic areas. With a commitment to innovation, precision and regulatory compliance, Anthem ensures its APIs meet stringent global standards, including USP, IP and JP grades.
Indications
- Hyperprolactinemia, prolactinomas, lactation suppression, Parkinson’s disease, uterine fibroids, acromegaly, erectile dysfunction.
Mechanism of Action
- Cabergoline inhibits prolactin synthesis and release from the anterior pituitary in a dose-dependent manner.
Dosage
- Hyperprolactinemia: Initial dose of 0.25 mg twice weekly; maximum dose of 1 mg twice weekly.
- Lactation suppression: Single dose of 1 mg within 24–27 hours post-delivery.
- Highly pure and stable USP EP-grade Cabergoline.
Anthem Advantage
- Highly pure and stable USP EP-grade Cabergoline.
Cabergoline (IP/USP)
Cabergoline is a potent dopamine receptor agonist primarily targeting D2 receptors. It is widely used for managing hyperprolactinemia and prolactinomas due to its high affinity for D2 receptor sites, minimal side effects and convenient dosing schedule.
Indications
- Blood cell disorders caused by folate antagonists, colon cancer (with 5-fluorouracil), anemia due to folic acid deficiency.
Mechanism of Action
Calcium folinate bypasses methotrexate-induced folic acid inhibition by replenishing reduced folate pools.
Dosage
- Megaloblastic anemia: One tablet daily.
Anthem Advantage
- High-purity formulations designed for therapeutic efficacy.
Calcium Folinate (IP/USP)
Calcium folinate is an active metabolite of folinic acid used as an essential coenzyme in nucleic acid synthesis. It serves as an adjuvant in cancer chemotherapy and counteracts the toxic effects of folate antagonists like methotrexate.
Indications
- Gynecology, anemia, cardiac health, neuropathy, cognitive performance, geriatrics.
Mechanism of Action
Enhances acetylcholine synthesis for improved memory and reduces homocysteine toxicity.
Anthem Advantage
- Synthetic enrichment ensures 99% purity for superior bioavailability.
L-Methyl Tetrahydrofolate Calcium (USP)
L-Methyl folate is the bioactive form of vitamin B9 essential for DNA production, red blood cell formation and homocysteine breakdown. It is particularly significant in preventing neural tube defects during pregnancy and addressing cardiovascular health.
Indications
- Contraception, breast cancer management, dysfunctional uterine bleeding.
Mechanism of Action
Exhibits selective estrogenic or anti-estrogenic activity depending on the tissue type. It prevents implantation by creating unfavorable conditions in the uterus.
Dosage
- Dysfunctional uterine bleeding: 60 mg twice weekly for the first 12 weeks; then once weekly for another 12 weeks.
- Contraception: Initial dose of 30 mg twice weekly for the first 12 weeks; followed by once weekly dosing.
Anthem Advantage
- High therapeutic index with proven safety and efficacy.
Ormeloxifine
Ormeloxifene is a non-steroidal Selective Estrogen Receptor Modulator (SERM) used as an oral contraceptive and in treating abnormal uterine bleeding and breast cancer.
Indications
- Chronic pancreatitis, cystic fibrosis, pancreatic cancer.
Mechanism of Action
Supports immune system health, enhances digestion of fats/proteins/carbohydrates, and aids cardiovascular health by reducing homocysteine levels.
Dosage
- Therapeutic doses range from 25,000–50,000 U based on individual needs.
Anthem Advantage
- Purified enzyme formulations for optimal digestive support.
Pancreatin (IP)
Pancreatin is a blend of digestive enzymes (amylase, lipase, protease) used to treat pancreatic insufficiency and improve nutrient absorption.
Applications
- Brewing industry for beer stabilization.
- Meat tenderization and protein hydrolysis.
- Pharmaceutical use in digestive aids and wound healing formulations.
- Leather processing and paper manufacturing.
- Contact lens cleaning solutions.
Therapeutic Uses
Treats herpes zoster, sore throat, diarrhea, hay fever, psoriasis, infected wounds.
Formulations
- Available in liquid/ syrup/ tablet/ capsule forms with standard strengths such as PapainX USP or Papain Liquid TU150.
Safety Handling
- Avoid prolonged skin contact; store below 10°C in airtight containers.
Papain (USP)
Papain is a natural proteolytic enzyme derived from papaya latex with extensive industrial and therapeutic applications.
Indications
- Pancreatic enzyme replacement in insufficiency, diarrhea, chronic gastritis, hypochlorhydria, postoperative digestive insufficiency.
Mechanism of Action
- Pepsin hydrolyzes peptide bonds, particularly those involving aromatic amino acids, contributing to partial protein digestion in the gastrointestinal tract.
Applications
- Supports digestion of hard-to-digest proteins.
- Stimulates bile production and liver detoxification.
- Boosts nutrient absorption and prevents deficiencies.
- Separates vitamin B12 from protein for effective utilization.
Safety Handling
- Airtight containers at temperatures below 10°C.
- Avoid prolonged skin contact; rinse thoroughly in case of spillage.
Pepsin (IP)
Pepsin is a proteolytic enzyme produced in the stomach that breaks down proteins into smaller peptides, aiding in digestion. It is derived from pepsinogen and activated by hydrochloric acid in gastric juice.
Indications
- Atherosclerosis, hypercholesterolemia, cancer prevention, herpes labialis infections.
Mechanism of Action
- Resveratrol protects cellular DNA from damage caused by free radicals and supports neuroprotection and anti-aging processes.
Applications
- Lowers blood pressure and improves cardiovascular health.
- Enhances insulin sensitivity and joint pain relief.
- Suppresses cancer cells and protects against brain degeneration.
Resveratrol
Resveratrol is a polyphenol found in grapes, red wine, peanuts and mulberry fruits. Known for its antioxidant properties, it offers wide-ranging health benefits.
Indications
- Anti-inflammatory conditions, bronchitis, sinusitis, laryngitis, gout, fibromyalgia.
Mechanism of Action
- Hydrolyzes bradykinin and histamine to reduce swelling and improve circulation while dissolving fibrin clots and arterial plaques.
Applications
- Treats arthritis, rheumatism, multiple sclerosis.
- Digests scar tissue and prevents fluid retention.
- Reduces blood clots and cysts.
Serratiopeptidase (IP)
Serratiopeptidase is a proteolytic enzyme derived from Serratia bacteria that reduces inflammation and aids tissue repair.
Indications
- CMV retinitis in AIDS patients; CMV disease prevention post-organ transplant; congenital CMV.
Mechanism of Action
Ganciclovir triphosphate inhibits viral DNA synthesis by targeting viral protein kinases.
Dosage
- Adults: Induction dose of 900 mg twice daily for CMV retinitis; maintenance dose of 900 mg once daily. Pediatric doses vary based on age and condition.
Valganciclovir (USP)
Valganciclovir is an antiviral drug converted into ganciclovir in the body to inhibit cytomegalovirus (CMV) replication.
Indications
- Non-insulin-dependent diabetes mellitus (NIDDM), steroid-induced diabetes mellitus, glycogen storage disease.
Mechanism of Action
Delays glucose absorption by inhibiting pancreatic alpha-amylase and intestinal alpha-glucosidase enzymes.
Dosage
- Typically administered at a dose of 0.2 mg three times daily before meals; can be increased to 0.3 mg if needed.
Voglibose (IP/JP)
Valganciclovir is an antiviral drug converted into ganciclovir in the body to inhibit cytomegalovirus (CMV) replication.
Anthem Biosciences continues to innovate and deliver world-class APIs tailored to meet diverse pharmaceutical needs while adhering to global regulatory standards.