HPAPI
Anthem has the capability to handle toxicity levels up to OEB 5, our infrastructure and expertise enable the synthesis of highly potent compounds for innovative targeted therapies.
End-to-End Solutions for HP APIs
Robust and scalable processes for synthesis
Stringent quality control and optimized process parameters
Safe handling practices and state-of-the-art containment solutions
Expertise in High-Potent Linkers and Toxins
Linkers
Anthem designs and synthesizes innovative linkers tailored to cleavable chemical moieties, our diverse portfolio includes:
Hydrazones | Peptides | Disulphides | Pegylated Linkers | Thioethers | Carbohydrates
Toxins
We handle multi-gram scale production of potent toxins, including:
Auristatins | Dolastatins | Maytansines | Calicheamicins | Duocarymycins | PBD Dimers | α-Amanitin
Linker-Toxin Conjugation
Ensuring complete containment during handling, our capabilities include:
- Batch production of up to 10 kg with scalability for multi-batch runs.
- High-quality conjugates tailored for targeted therapeutic applications.
Containment
17 isolators dedicated to high-potent operations, qualified for OEB 5 with an OEL of 1 µg/m³
Reactors
Precision reactions in all-glass jacketed reactors (5L, 10L, and 20L)
Purification
Advanced purification technologies like Column Chromatography and Vacuum Tray Drying
Lyophilization
A 30 kg capacity lyo facility for controlled drying processes
Anthem’s cGMP Containment Facilities
Global Standards Compliance
Our processes and facilities meet global pharmacopoeia standards, including:
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USP/NF | EP | BP | JP | ACS | AOAC
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We integrate client-provided methods, ensuring bespoke solutions that meet specific regulatory requirements
Certifications and Safety Standards
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21 CFR Part 11 Compliance | CAIH Certified | ISPE-Validated Isolators