Large Molecules
Pioneering Biologics and Advanced Therapeutics
Anthem offers a full spectrum of large molecule CDMO services, supporting clients from early discovery through to commercial manufacturing. Our expertise spans:
Mammalian Cell Culture
Gold standard for producing complex, glycosylated proteins such as monoclonal antibodies, fusion proteins and therapeutic enzymes.
Microbial Fermentation
Rapid, cost-effective production of recombinant proteins, peptides and vaccines using systems like E. coli and Saccharomyces cerevisiae.
Antibody-Drug Conjugates
Integrated development and manufacturing of targeted therapies, combining biologics with cytotoxic payloads for precision oncology.
mRNA & Oligonucleotides
Specialized services for mRNA synthesis, lipid nanoparticle (LNP) formulation and gene therapy applications.
Large Molecule Modalities
Large molecule drugs, or biologics, have become a cornerstone of modern biopharmaceutical development. These complex therapeutics, including monoclonal antibodies, fusion proteins, recombinant enzymes and gene therapies, offer targeted treatment options for cancers, autoimmune diseases and genetic disorders.
Mammalian Cell Line and Process Development
Mammalian cell culture remains the gold standard for producing complex, glycosylated proteins such as monoclonal antibodies (mAbs), fusion proteins and therapeutic enzymes.
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Use of CHO and HEK293 cell lines for robust protein expression.
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Design of Experiments (DOE) to optimize productivity and quality.
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GMP-compliant process development supporting IND to BLA filings.
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Seamless tech transfer and scale-up from lab to commercial scale.
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Clone development using recombinant DNA technology.
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Strain improvement via genetic and metabolic engineering.
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Optimization of fermentation parameters for maximal yield and quality.
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Expertise in downstream protein purification.
Microbial Cell Line and Process Development
Microbial fermentation platforms such as Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, and Pichia pastoris offer rapid growth, cost efficiency and scalability for producing recombinant proteins, peptides and vaccines.
Antibody-Drug Conjugates (ADCs) and Bioconjugates
ADCs combine the specificity of monoclonal antibodies with the cytotoxic power of small molecule drugs, enabling targeted cancer therapies with reduced systemic toxicity.
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Conjugation chemistry ensures stable and effective linker-payload attachment.
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Conjugation chemistry ensures stable and effective linker-payload attachment.
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Advanced quality control protocols to meet stringent regulatory standards.
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mRNA synthesis and sequence optimization.
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Lipid nanoparticle formulation for efficient delivery and cellular uptake.
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GMP manufacturing with scalable production capabilities.
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In vitro and in vivo characterization, stability testing and regulatory support.
mRNA and Lipid Nanoparticles
mRNA therapeutics represent a transformative modality for treating infectious diseases, cancer and genetic disorders. Anthem offers specialized services including:
Why Partner with Anthem for Large Molecules?
Scientific Expertise
Our multidisciplinary teams bring deep experience in cell line development, process optimization and analytical characterization, ensuring robust and reproducible results.
Regulatory Compliance
We operate state-of-the-art, GMP-compliant facilities and adhere to stringent global regulatory standards, supporting smooth IND, BLA and global submissions.
Scalability & Flexibility
From lab-scale to commercial production, our infrastructure supports seamless scale-up, tech transfer and multi-product manufacturing.
Integrated Solutions
We offer a unified approach, integrating discovery, development and manufacturing under one roof for accelerated timelines and reduced risk.
Discovery & Preclinical
- Protein sciences, molecular biology and antibody generation
- Cell line and strain development
- Preclinical evaluation and non-GMP manufacturing
Clinical & Commercial Manufacturing
- Biologics process development (upstream and downstream)
- Analytical development and characterization
- GMP manufacturing for clinical and commercial supply