Oligonucleotides

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Anthem provides integrated solutions in custom oligonucleotides and phosphoramidite building blocks for drug discovery, diagnostics, and research. Our capabilities span ASOs, siRNA, mRNA, aptamers, gapmers, gRNA and both standard and modified phosphoramidite chemistries.

Comprehensive Solutions for Oligonucleotides

Diverse Therapeutic Portfolio

Capabilities spanning ASOs, siRNA, mRNA, aptamers, gapmers, and gRNA tailored for drug discovery and diagnostics.

Advanced Chemical Synthesis

Expertise in both standard and modified phosphoramidite chemistries delivering reliable building block solutions.

End-to-End CMC Support

Integrated solutions providing complete Chemistry, Manufacturing, and Controls support from research to delivery.

Analytical Solutions and Characterization

Analytical Solutions

  • Structural characterization and assays using NMR ($^1H$, $^{31}P$, $^{19}F$) and mass spectrometry.

  • Analytical method development and validation for UHPLC, HPLC, SEC, IC, and GC-MS.

  • Sequence identification, impurity quantitation, and HRMS mass confirmation (Orbitrap Exploris 240).

  • Elemental impurity analysis (ICP-MS).

  • Bacterial bioburden and endotoxin testing.

  • Stability studies.

Specialized teams focused on advanced chemistry development, process optimization, and reliable scale-up.

GMP Manufacturing

Backed by state-of-the-art, GMP-certified manufacturing facilities enabling scalable and high-quality solutions.

High-Res MS

Sequence identification and HRMS mass confirmation utilizing the Orbitrap Exploris 240 system.

Impurity Analysis

Rigorous elemental impurity analysis utilizing ICP-MS to ensure minimal impurity levels.

Chromatography

Advanced separation capabilities including UHPLC, HPLC, SEC, IC, and GC-MS.

Manufacturing & Instrumentation Capabilities

Quality Attributes

Anthem upholds the highest standards of quality, confidentiality, and ethics through rigorously controlled processes.

  • QC-approved materials ensuring consistent reproducibility.
  • Minimal impurity levels in phosphoramidite and oligonucleotide synthesis.

Certifications and Standards

  • GMP-Certified Manufacturing.
  • Dedicated PNS and Phosphoramidite Chemistry Division.